Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development

Highlights • Glucocorticoid (GC) exposure in early placentation induces preeclampsia (PE) in rats. • GC inhibits trophoblast development both in vivo and in vitro. • GC exposure leads to rat PE partially via inhibiting trophoblast invasion and EMT. • GC receptor and ERK are involved in the inhibitio...

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Veröffentlicht in:	General and comparative endocrinology 2016-01, Vol.225, p.61-70
Hauptverfasser:	Zhang, Dongxin, Liu, Haojing, Zeng, Ji, Miao, Xili, Huang, Wei, Chen, Hongxiang, Huang, Yinping, Li, Yongsheng, Ye, Duyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dexamethasone - pharmacology Down-Regulation - drug effects Endocrinology & Metabolism Epithelial–mesenchymal transition Female Glucocorticoid Glucocorticoids - pharmacology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Male Oxidative Stress - drug effects Placenta - drug effects Placenta - metabolism Placenta - pathology Placentation Placentation - drug effects Pre-Eclampsia - chemically induced Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Preeclampsia Pregnancy Rats Trophoblast development Trophoblasts - drug effects Trophoblasts - metabolism Trophoblasts - pathology
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Zusammenfassung:	Highlights • Glucocorticoid (GC) exposure in early placentation induces preeclampsia (PE) in rats. • GC inhibits trophoblast development both in vivo and in vitro. • GC exposure leads to rat PE partially via inhibiting trophoblast invasion and EMT. • GC receptor and ERK are involved in the inhibition of GC on trophoblast development.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.09.019