The effect of long-term corticosterone treatment on blood cell differentials and function in laboratory and wild-caught amphibian models

Highlights • The effect of long-term stress on amphibian immunity is not well understood. • We elevated plasma corticosterone in Xenopus laevis and Lithobates catesbeianus. • Long-term elevated corticosterone altered blood cell differentials and function. • Stressful habitat conditions may alter amp...

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Veröffentlicht in:	General and comparative endocrinology 2015-02, Vol.212, p.73-83
Hauptverfasser:	Falso, Paul G, Noble, Christopher A, Diaz, Jesus M, Hayes, Tyrone B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibian Animals Anti-Inflammatory Agents - blood Anti-Inflammatory Agents - pharmacology Anura Cells, Cultured Corticosterone Corticosterone - blood Corticosterone - pharmacology Endocrine System - drug effects Endocrinology & Metabolism Eosinophils - drug effects Eosinophils - metabolism Immunoassay Leukocyte Leukocytes - drug effects Leukocytes - metabolism Lymphocytes - drug effects Lymphocytes - metabolism Monocytes - drug effects Monocytes - metabolism Neutrophils - drug effects Neutrophils - metabolism Oxidative burst Rana catesbeiana Rana catesbeiana - physiology Stress Xenopus laevis Xenopus laevis - physiology
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Zusammenfassung:	Highlights • The effect of long-term stress on amphibian immunity is not well understood. • We elevated plasma corticosterone in Xenopus laevis and Lithobates catesbeianus. • Long-term elevated corticosterone altered blood cell differentials and function. • Stressful habitat conditions may alter amphibian immunity for long-term periods.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.01.003