Discovery and functional characterization of leptin and its receptors in Japanese quail ( Coturnix japonica )

Highlights • LEP and four leptin receptor isoforms were obtained firstly in Japanese quail. • qLEP and the four qLEPR isoforms were expressed extensively in all tissues examined. • Fasting increases and refeeding decreases LEP and LEPR expressions of juvenile quail. • LEP may actually act to inhibit...

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Veröffentlicht in:General and comparative endocrinology 2016-01, Vol.225, p.1-12
Hauptverfasser: Wang, Dandan, Xu, Chunlin, Wang, Taian, Li, Hong, Li, Yanmin, Ren, Junxiao, Tian, Yadong, Li, Zhuanjian, Jiao, Yuping, Kang, Xiangtao, Liu, Xiaojun
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container_title General and comparative endocrinology
container_volume 225
creator Wang, Dandan
Xu, Chunlin
Wang, Taian
Li, Hong
Li, Yanmin
Ren, Junxiao
Tian, Yadong
Li, Zhuanjian
Jiao, Yuping
Kang, Xiangtao
Liu, Xiaojun
description Highlights • LEP and four leptin receptor isoforms were obtained firstly in Japanese quail. • qLEP and the four qLEPR isoforms were expressed extensively in all tissues examined. • Fasting increases and refeeding decreases LEP and LEPR expressions of juvenile quail. • LEP may actually act to inhibit food intake during fasting, at least in juvenile quail. • qLEP and qLEPR may play important roles in regulating reproduction and energy status.
doi_str_mv 10.1016/j.ygcen.2015.09.003
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subjects Age Factors
Alternative splicing
Amino Acid Sequence
Animals
Carrier Proteins - metabolism
Cloning, Molecular
Coturnix - metabolism
Eating - genetics
Endocrinology & Metabolism
Exons
Female
Gene cloning
Hypothalamus - metabolism
LEPR
Leptin
Leptin - genetics
Leptin - metabolism
Ovary - metabolism
Physiological function
Pituitary Gland - metabolism
Quail
Receptors, Leptin - genetics
Receptors, Leptin - metabolism
title Discovery and functional characterization of leptin and its receptors in Japanese quail ( Coturnix japonica )
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