Discovery and functional characterization of leptin and its receptors in Japanese quail ( Coturnix japonica )

Highlights • LEP and four leptin receptor isoforms were obtained firstly in Japanese quail. • qLEP and the four qLEPR isoforms were expressed extensively in all tissues examined. • Fasting increases and refeeding decreases LEP and LEPR expressions of juvenile quail. • LEP may actually act to inhibit...

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Veröffentlicht in:	General and comparative endocrinology 2016-01, Vol.225, p.1-12
Hauptverfasser:	Wang, Dandan, Xu, Chunlin, Wang, Taian, Li, Hong, Li, Yanmin, Ren, Junxiao, Tian, Yadong, Li, Zhuanjian, Jiao, Yuping, Kang, Xiangtao, Liu, Xiaojun
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alternative splicing Amino Acid Sequence Animals Carrier Proteins - metabolism Cloning, Molecular Coturnix - metabolism Eating - genetics Endocrinology & Metabolism Exons Female Gene cloning Hypothalamus - metabolism LEPR Leptin Leptin - genetics Leptin - metabolism Ovary - metabolism Physiological function Pituitary Gland - metabolism Quail Receptors, Leptin - genetics Receptors, Leptin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • LEP and four leptin receptor isoforms were obtained firstly in Japanese quail. • qLEP and the four qLEPR isoforms were expressed extensively in all tissues examined. • Fasting increases and refeeding decreases LEP and LEPR expressions of juvenile quail. • LEP may actually act to inhibit food intake during fasting, at least in juvenile quail. • qLEP and qLEPR may play important roles in regulating reproduction and energy status.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.09.003