TAB3 involves in hepatic insulin resistance through activation of MAPK pathway

Highlights • TAB3 acts as a negative regulator of insulin sensitivity. • TAB3 has different effect on activation of ERK, JNK and p38 MAPK. • We linked MAPK pathway to insulin resistance. • We reported the sole role of TAB3 independent of TAK1.

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Veröffentlicht in:	General and comparative endocrinology 2015-12, Vol.224, p.228-234
Hauptverfasser:	Zhao, Yun, Tang, Zhuqi, Zhu, Xiaohui, Wang, Xueqin, Wang, Cuifang, Zhang, Wanlu, Xia, Nana, Wang, Suxin, Huang, Jieru, Cui, Shiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Blotting, Western Endocrinology & Metabolism Hep G2 Cells Humans Insulin - metabolism Insulin resistance Insulin Resistance - physiology Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Liver - cytology Liver - metabolism Male MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAPKs Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Protein Binding Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Signal Transduction TAB3 Type 2 diabetes
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Beschreibung
Zusammenfassung:	Highlights • TAB3 acts as a negative regulator of insulin sensitivity. • TAB3 has different effect on activation of ERK, JNK and p38 MAPK. • We linked MAPK pathway to insulin resistance. • We reported the sole role of TAB3 independent of TAK1.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.08.019