β-asarone and levodopa co-administration increase striatal dopamine level in 6-hydroxydopamine induced rats by modulating P-glycoprotein and tight junction proteins at the blood-brain barrier and promoting levodopa into the brain

Summary Levodopa (L‐dopa) is widely considered as one of the most effective drug constituents in the treatment of Parkinson's disease (PD), but the blood‐brain barrier (BBB) permeability of L‐dopa is

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2016-06, Vol.43 (6), p.634-643
Hauptverfasser:	Huang, Liping, Deng, Minzhen, He, Yuping, Lu, Shiyao, Ma, Ruanxin, Fang, Yongqi
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Animals Anisoles - administration & dosage ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors ATP Binding Cassette Transporter, Sub-Family B - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism claudin-5 Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Drug Therapy, Combination Levodopa - administration & dosage Levodopa - metabolism occluding Oxidopamine - toxicity P-glycoprotein Parkinsonian Disorders - chemically induced Parkinsonian Disorders - metabolism Parkinsonian Disorders - prevention & control Rats Tight Junction Proteins - antagonists & inhibitors Tight Junction Proteins - metabolism zonula occludens-1 β-asarone
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Zusammenfassung:	Summary Levodopa (L‐dopa) is widely considered as one of the most effective drug constituents in the treatment of Parkinson's disease (PD), but the blood‐brain barrier (BBB) permeability of L‐dopa is
ISSN:	0305-1870 1440-1681
DOI:	10.1111/1440-1681.12570