Expression of mRNA in the frontal cortex and hypothalamus in a rat model of acute carbon dioxide poisoning

Highlights • We made a rat model of acute CO2 poisoning and analyzed mRNAs expressed in the brain. • We selected five candidate genes in the frontal cortex and hypothalamus respectively. • AGPS, HSPB2 may be involved in the dysfunctional cognition by acute CO2 poisoning. • PPY, CRHR2 may be involved...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Legal medicine (Tokyo, Japan) Japan), 2016-03, Vol.19, p.101-106
Hauptverfasser:	Sato, Kazuo, Tsuji, Akiko, Usumoto, Yosuke, Kudo, Keiko, Yokoyama, Takeshi, Ikeda, Noriaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Dioxide - poisoning Disease Models, Animal Frontal Lobe - metabolism Hypothalamus - metabolism Internal Medicine Male mRNA Pathophysiology Rats Rats, Wistar RNA, Messenger - metabolism The frontal cortex The hypothalamus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We made a rat model of acute CO2 poisoning and analyzed mRNAs expressed in the brain. • We selected five candidate genes in the frontal cortex and hypothalamus respectively. • AGPS, HSPB2 may be involved in the dysfunctional cognition by acute CO2 poisoning. • PPY, CRHR2 may be involved in the regulation of respiration by acute CO2 poisoning. • Assays for these mRNAs may help identify acute CO2 poisoning as a cause of death.
ISSN:	1344-6223 1873-4162
DOI:	10.1016/j.legalmed.2015.07.014