Melonoside A: An ω‑Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae

Melonoside A: An ω‑Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae

Melonoside A (1), the first representative of a new class of ω-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge Melonanchora kobjakovae. The structure of 1, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra...

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Veröffentlicht in:Organic letters 2016-07, Vol.18 (14), p.3478-3481
Hauptverfasser: Guzii, Alla G, Makarieva, Tatyana N, Denisenko, Vladimir A, Dmitrenok, Pavel S, Kuzmich, Aleksandra S, Dyshlovoy, Sergey A, von Amsberg, Gunhild, Krasokhin, Vladimir B, Stonik, Valentin A
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Sprache:eng
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Zusammenfassung:Melonoside A (1), the first representative of a new class of ω-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge Melonanchora kobjakovae. The structure of 1, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 induces autophagy of human cisplatin-resistant germinal tumor cells NCCIT-R.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01678