Synthesis and Biological Activities of 8′-Methylene- and 8′-Methylidyneabscisic Acids

8′-Methylene- and 8′-methylidyneabscisic acids which might act as suicide inhibitors of the 8′-hydroxylase of abscisic acid, were designed, synthesized, and optically resolved. The (+)-isomers showed stronger inhibitory activity in rice elongation and in lettuce seed germination than (+)-abscisic ac...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997-01, Vol.61 (12), p.2043-2045
Hauptverfasser:	Todoroki, Yasushi, Nakano, Sei-ichi, Arai, Sho, Hirai, Nobuhiro, Ohigashi, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	8′-methyleneabscisic acid 8′-methylidyneabscisic acid abscisic acid Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry cytochrome P-450 monooxygenase Exact sciences and technology Organic chemistry Preparations and properties suicide inhibitor Terpenoids
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Beschreibung
Zusammenfassung:	8′-Methylene- and 8′-methylidyneabscisic acids which might act as suicide inhibitors of the 8′-hydroxylase of abscisic acid, were designed, synthesized, and optically resolved. The (+)-isomers showed stronger inhibitory activity in rice elongation and in lettuce seed germination than (+)-abscisic acid. The activity of (+)-8′-methylidyneabscisic acid was the strongest of the analogues synthesized to date, 40-fold stronger than abscisic acid.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.61.2043