Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren

SCOPE: This study explores the relationship between aflatoxin and the insulin‐like growth factor (IGF) axis and its potential effect on child growth. METHODS AND RESULTS: One hundred and ninety‐nine Kenyan schoolchildren were studied for aflatoxin‐albumin adduct (AF‐alb), IGF1 and IGF‐binding protei...

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Veröffentlicht in:	Molecular nutrition & food research 2015-03, Vol.59 (3), p.574-581
Hauptverfasser:	Castelino, Jovita M, Routledge, Michael N, Wilson, Shona, Dunne, David W, Mwatha, Joseph K, Gachuhi, Kimani, Wild, Christopher P, Gong, Yun Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent aflatoxin B1 Aflatoxin B1 - toxicity Aflatoxins Aflatoxins - blood Aflatoxins - toxicity Albumins Body Height - drug effects Body Weight - drug effects Cell Line - drug effects Child Child growth Cross-Sectional Studies culture media enzyme-linked immunosorbent assay Exposure biomarker Female Food Contamination - analysis gene expression gene expression regulation genes hepatocytes Hepatocytes - drug effects Humans IGFBP3 Insulin-like growth factor Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor I - genetics Kenya Male quantitative polymerase chain reaction school children somatomedins
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Zusammenfassung:	SCOPE: This study explores the relationship between aflatoxin and the insulin‐like growth factor (IGF) axis and its potential effect on child growth. METHODS AND RESULTS: One hundred and ninety‐nine Kenyan schoolchildren were studied for aflatoxin‐albumin adduct (AF‐alb), IGF1 and IGF‐binding protein‐3 (IGFBP3) levels using ELISA. AF‐alb was inversely associated with IGF1 and IGFBP3 (p < 0.05). Both IGF1 and IGFBP3 were significantly associated with child height and weight (p < 0.01). Children in the highest tertile of AF‐alb exposure (>198.5 pg/mg) were shorter than children in the lowest tertile (
ISSN:	1613-4125 1613-4133
DOI:	10.1002/mnfr.201300619