Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP

In this study, we investigated the role of c-Myc/ATF4/CHOP signaling pathway in sensitization of human hepatoma HepG2 cells to TRAIL. Knockdown of SIRT1 or treatment with SIRT1 inhibitor caused the up-regulation of DR5 and down-regulation of c-FLIP through modulation of c-Myc/ATF4/CHOP pathway, and...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2013-03, Vol.45 (3), p.711-723
Hauptverfasser:	Kim, Mi-Ju, Hong, Kyung-Soo, Kim, Hak-Bong, Lee, Su-Hoon, Bae, Jae-Ho, Kim, Dong-Wan, Dao, Trong Tuan, Oh, Won Keun, Kang, Chi-Dug, Kim, Sun-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Activating Transcription Factor 4 - metabolism Animals Antigens, Nuclear - metabolism apoptosis Apoptosis - genetics c-Myc CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism Cell Proliferation CHOP cytotoxicity DNA-Binding Proteins - metabolism Down-Regulation Hep G2 Cells hepatoma human cell lines Humans Ku Autoantigen Ku70 Mice Proto-Oncogene Proteins c-myc - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Signal Transduction SIRT1 Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - genetics Sirtuin 1 - metabolism synergism TNF-Related Apoptosis-Inducing Ligand - metabolism TRAIL Transcription Factor CHOP - metabolism
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