Synthesis of Androprostamine A and Resormycin

Syntheses of androprostamine A (1), and resormycin (3), anti-prostate cancer peptidyl natural products produced by microorganisms, were completed. The characteristic enamide structures of these compounds were installed using the Horner-Wadsworth-Emmons reaction from the corresponding phosphonates in...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/07/01, Vol.64(7), pp.982-987
Hauptverfasser:	Abe, Hikaru, Yamazaki, Yohko, Sakashita, Chiharu, Momose, Isao, Watanabe, Takumi, Shibasaki, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor agent Cinnamates - chemical synthesis Cinnamates - chemistry Molecular Structure natural product Oligopeptides - chemical synthesis Oligopeptides - chemistry Propionates - chemical synthesis Propionates - chemistry prostate cancer Stereoisomerism synthesis
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Beschreibung
Zusammenfassung:	Syntheses of androprostamine A (1), and resormycin (3), anti-prostate cancer peptidyl natural products produced by microorganisms, were completed. The characteristic enamide structures of these compounds were installed using the Horner-Wadsworth-Emmons reaction from the corresponding phosphonates in reasonable Z-selectivity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c16-00207