Conversion of Vindoline into 11-Mesyloxytabersonine

Conversion of Vindoline into 11-Mesyloxytabersonine

Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 2016/07/01, Vol.64(7), pp.800-804
Hauptverfasser: Han-ya, Yuki, Inui, Tomohiko, Yokoshima, Satoshi, Tokuyama, Hidetoshi, Fukuyama, Tohru
Format: Artikel
Sprache:eng
Schlagworte:
alkaloid
indole
Indole Alkaloids - chemical synthesis
Indole Alkaloids - chemistry
Molecular Conformation
natural product
tabersonine
Vinblastine - analogs & derivatives
Vinblastine - chemistry
vindoline
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Beschreibung
Zusammenfassung:Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c16-00175