Nuclear Y-Box-binding Protein-1 Expression Predicts Poor Clinical Outcome in Stage III Colorectal Cancer

Y-Box-binding protein-1 (YB-1), a DNA/RNA-binding protein, is an important oncogenic transcription and translation factor. We aimed to evaluate the relationships between nuclear YB-1 expression, epidermal growth factor receptor (EGFR) status, and poor clinical outcomes in patients with colorectal ca...

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Veröffentlicht in:	Anticancer research 2016-07, Vol.36 (7), p.3781-3788
Hauptverfasser:	Shiraiwa, Sachiko, Kinugasa, Tetsushi, Kawahara, Akihiko, Mizobe, Tomoaki, Ohchi, Takafumi, Yuge, Kotaro, Fujino, Shinya, Katagiri, Mitsuhiro, Shimomura, Susumu, Tajiri, Kensuke, Sudo, Tomoya, Kage, Masayoshi, Kuwano, Michihiko, Akagi, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cell Nucleus - metabolism Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Humans Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local - metabolism Neoplasm Staging Prognosis Proportional Hazards Models Receptor, Epidermal Growth Factor - metabolism Treatment Outcome Y-Box-Binding Protein 1 - metabolism
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Zusammenfassung:	Y-Box-binding protein-1 (YB-1), a DNA/RNA-binding protein, is an important oncogenic transcription and translation factor. We aimed to evaluate the relationships between nuclear YB-1 expression, epidermal growth factor receptor (EGFR) status, and poor clinical outcomes in patients with colorectal cancer (CRC). Nuclear YB-1 expression was immunohistochemically analyzed in CRC tissues obtained from 124 patients who underwent curative resection between 2005 and 2008. Correlations between nuclear YB-1 expression, various clinicopathological characteristics, EGFR status, and prognostic factors were evaluated. High-grade nuclear YB-1 expression was detected in 62.9% of cases and was found to be an independent predictor of poorer overall survival (p
ISSN:	1791-7530