Significance of the ADC ratio in the differential diagnosis of breast lesions

Background Magnetic resonance imaging (MRI) has high sensitivity but low specificity for breast cancer, and consequently, new techniques to improve the specificity of breast MRI in diagnosing breast cancer are under development. Purpose To assess the ability of the apparent diffusion coefficient (AD...

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Veröffentlicht in:Acta radiologica (1987) 2016-04, Vol.57 (4), p.422-429
Hauptverfasser: Zhao, Jinli, Guan, Haitao, Li, Minda, Gu, Hongmei, Qin, Jufeng, Wu, Xianhua
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Sprache:eng
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Zusammenfassung:Background Magnetic resonance imaging (MRI) has high sensitivity but low specificity for breast cancer, and consequently, new techniques to improve the specificity of breast MRI in diagnosing breast cancer are under development. Purpose To assess the ability of the apparent diffusion coefficient (ADC) compared with the ADC ratio (ADCr) to differentially diagnose benign compared with malignant breast lesions. Material and Methods Forty-eight women with breast lesions (average age, 45 years) underwent MRI scanning including T1-weighted dynamic contrast-enhanced (DCE) scanning and diffusion-weighted imaging (DWI). The average ADC and ADCr values for both lesions and pectoralis major muscles (ADCrmuscle and ADCrmuscle) were measured in patients with malignant (n = 25) and benign (n = 23) breast lesions. The ADCr of the contralateral breast (ADCr contralateral) was also evaluated. All histology was confirmed by pathological analysis of biopsied tissue. ADC and ADCr values were analyzed using receiver-operating characteristic (ROC) curves. Results For benign lesions compared with malignant lesions, lesion-side ADC was 1.45 vs. 1.05, respectively (P 
ISSN:0284-1851
1600-0455
DOI:10.1177/0284185115590286