Comparison Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy
Fractional flow reserve (FFR) has been established as gold standard to detect hemodynamically significant coronary artery disease. Non-invasive FFR derived from coronary computed tomography angiography (CTA; FFR CT ) has demonstrated higher diagnostic performance compared with FFR. However, the accu...
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| Veröffentlicht in: | Annals of biomedical engineering 2016-02, Vol.44 (2), p.580-589 |
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| description | Fractional flow reserve (FFR) has been established as gold standard to detect hemodynamically significant coronary artery disease. Non-invasive FFR derived from coronary computed tomography angiography (CTA; FFR
CT
) has demonstrated higher diagnostic performance compared with FFR. However, the accuracy and potential advantages of FFR
CT
compared with invasive FFR in coronary arteries with serial lesions have not been examined. The aim of this study was to compare trans-lesional gradient in FFR
CT
to that in invasive FFR in coronary arteries with serial stenoses. Eighteen vessels with serial coronary lesions from 18 stable angina patients were evaluated with angiography, FFR, and coronary CTA. FFR
CT
was computed from 3-dimensional CT model and coronary flow dynamics data. Multiple FFR
CT
values were co-registered with measured FFR across the lesions, and trans-lesional delta were compared between FFR
CT
and FFR. The mean values of the most distal FFR and FFR
CT
in the same co-registered regions were 0.72 ± 0.10 and 0.69 ± 0.11, respectively. In 13 vessels (72.2%), FFR was ≤0.80, while in 14 vessels (77.8%), FFR
CT
was ≤0.80. Trans-lesional delta FFR and FFR
CT
were 0.10 ± 0.09 and 0.09 ± 0.10 in distal segments, while 0.17 ± 0.10 and 0.22 ± 0.13 in proximal segments, respectively. The coefficient of correlation between trans-lesional delta FFR and FFR
CT
in each segment was 0.92 (
p
|
| doi_str_mv | 10.1007/s10439-015-1436-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1800500147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1768169553</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-76e1cc461061f18706b25598d8da171d23c155001ba047c16b16d2ed9ddcc4423</originalsourceid><addsrcrecordid>eNqNktFu0zAUhiMEYmXwANwgS9yMC4NPHDsJd6VQmDRtiBXBXeTEp52n1C62syqPyFvhrt2EkBBc2XK-73d89GfZc2CvgbHyTQBW8JoyEBQKLun4IJuAKDmtZSUfZhPGakZlLYuj7EkI14wBVFw8zo5yyfO6zvkk-zlz643yJjhL3mHcIlpy7iw19kYFc4PkZOa8s8qPZEcOETVZuLVbebW5GsnUrszd_j36JOhXRFlNTg8-nXvVRZMSejLv3ZZ8wYA-5RpLPqto0MZAtiZekcukJ-gyonUBA_mWDhN0YZHc_8LUR_TjWzIl598XZHErhKENcdDj0-zRUvUBnx3W4-zr_MNi9omeXXw8nU3PaCdYFWkpEbqukMAkLKEqmWxzIepKV1pBCTrnHQiRRtUqVpQdyBakzlHXWietyPlxdrLP3Xj3Y8AQm7UJHfa9suiG0EDF2M4vyn-jZSml5HVe_QcqK5C1EDyhL_9Ar93g04BvA4FVMr0jUbCnOu9C8LhsNt6s0xAbYM2uPc2-PU1qT7NrTzMm58UheWjXqO-Nu7okIN8DIX2yK_S_Xf3X1F8ti9Ga</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771086171</pqid></control><display><type>article</type><title>Comparison Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tanaka, Kentaro ; Bezerra, Hiram G. ; Gaur, Sara ; Attizzani, Guilherme F. ; Bøtker, Hans Erik ; Costa, Marco A. ; Rogers, Campbell ; Nørgaard, Bjarne L.</creator><creatorcontrib>Tanaka, Kentaro ; Bezerra, Hiram G. ; Gaur, Sara ; Attizzani, Guilherme F. ; Bøtker, Hans Erik ; Costa, Marco A. ; Rogers, Campbell ; Nørgaard, Bjarne L.</creatorcontrib><description>Fractional flow reserve (FFR) has been established as gold standard to detect hemodynamically significant coronary artery disease. Non-invasive FFR derived from coronary computed tomography angiography (CTA; FFR
CT
) has demonstrated higher diagnostic performance compared with FFR. However, the accuracy and potential advantages of FFR
CT
compared with invasive FFR in coronary arteries with serial lesions have not been examined. The aim of this study was to compare trans-lesional gradient in FFR
CT
to that in invasive FFR in coronary arteries with serial stenoses. Eighteen vessels with serial coronary lesions from 18 stable angina patients were evaluated with angiography, FFR, and coronary CTA. FFR
CT
was computed from 3-dimensional CT model and coronary flow dynamics data. Multiple FFR
CT
values were co-registered with measured FFR across the lesions, and trans-lesional delta were compared between FFR
CT
and FFR. The mean values of the most distal FFR and FFR
CT
in the same co-registered regions were 0.72 ± 0.10 and 0.69 ± 0.11, respectively. In 13 vessels (72.2%), FFR was ≤0.80, while in 14 vessels (77.8%), FFR
CT
was ≤0.80. Trans-lesional delta FFR and FFR
CT
were 0.10 ± 0.09 and 0.09 ± 0.10 in distal segments, while 0.17 ± 0.10 and 0.22 ± 0.13 in proximal segments, respectively. The coefficient of correlation between trans-lesional delta FFR and FFR
CT
in each segment was 0.92 (
p
< 0.001). Trans-lesional delta FFR and FFR
CT
show an excellent correlation. Further studies are required to determine the diagnostic accuracy and clinical impact of our findings.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-015-1436-y</identifier><identifier>PMID: 26329923</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Angiography ; Arteries ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Blood vessels ; Classical Mechanics ; Computation ; Computed tomography ; Coronary Angiography ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - physiopathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Deltas ; Female ; Fractional Flow Reserve, Myocardial ; Humans ; Lesions ; Male ; Medical Stents: State of the Art and Future Directions ; Middle Aged ; Prospective Studies ; Segments ; Serials ; Tomography, X-Ray Computed</subject><ispartof>Annals of biomedical engineering, 2016-02, Vol.44 (2), p.580-589</ispartof><rights>Biomedical Engineering Society 2015</rights><rights>Biomedical Engineering Society 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-76e1cc461061f18706b25598d8da171d23c155001ba047c16b16d2ed9ddcc4423</citedby><cites>FETCH-LOGICAL-c508t-76e1cc461061f18706b25598d8da171d23c155001ba047c16b16d2ed9ddcc4423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-015-1436-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-015-1436-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26329923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Kentaro</creatorcontrib><creatorcontrib>Bezerra, Hiram G.</creatorcontrib><creatorcontrib>Gaur, Sara</creatorcontrib><creatorcontrib>Attizzani, Guilherme F.</creatorcontrib><creatorcontrib>Bøtker, Hans Erik</creatorcontrib><creatorcontrib>Costa, Marco A.</creatorcontrib><creatorcontrib>Rogers, Campbell</creatorcontrib><creatorcontrib>Nørgaard, Bjarne L.</creatorcontrib><title>Comparison Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>Fractional flow reserve (FFR) has been established as gold standard to detect hemodynamically significant coronary artery disease. Non-invasive FFR derived from coronary computed tomography angiography (CTA; FFR
CT
) has demonstrated higher diagnostic performance compared with FFR. However, the accuracy and potential advantages of FFR
CT
compared with invasive FFR in coronary arteries with serial lesions have not been examined. The aim of this study was to compare trans-lesional gradient in FFR
CT
to that in invasive FFR in coronary arteries with serial stenoses. Eighteen vessels with serial coronary lesions from 18 stable angina patients were evaluated with angiography, FFR, and coronary CTA. FFR
CT
was computed from 3-dimensional CT model and coronary flow dynamics data. Multiple FFR
CT
values were co-registered with measured FFR across the lesions, and trans-lesional delta were compared between FFR
CT
and FFR. The mean values of the most distal FFR and FFR
CT
in the same co-registered regions were 0.72 ± 0.10 and 0.69 ± 0.11, respectively. In 13 vessels (72.2%), FFR was ≤0.80, while in 14 vessels (77.8%), FFR
CT
was ≤0.80. Trans-lesional delta FFR and FFR
CT
were 0.10 ± 0.09 and 0.09 ± 0.10 in distal segments, while 0.17 ± 0.10 and 0.22 ± 0.13 in proximal segments, respectively. The coefficient of correlation between trans-lesional delta FFR and FFR
CT
in each segment was 0.92 (
p
< 0.001). Trans-lesional delta FFR and FFR
CT
show an excellent correlation. Further studies are required to determine the diagnostic accuracy and clinical impact of our findings.</description><subject>Aged</subject><subject>Angiography</subject><subject>Arteries</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Blood vessels</subject><subject>Classical Mechanics</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Coronary Angiography</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Deltas</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Humans</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical Stents: State of the Art and Future Directions</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Segments</subject><subject>Serials</subject><subject>Tomography, X-Ray 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Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy</title><author>Tanaka, Kentaro ; Bezerra, Hiram G. ; Gaur, Sara ; Attizzani, Guilherme F. ; Bøtker, Hans Erik ; Costa, Marco A. ; Rogers, Campbell ; Nørgaard, Bjarne L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-76e1cc461061f18706b25598d8da171d23c155001ba047c16b16d2ed9ddcc4423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Arteries</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Blood vessels</topic><topic>Classical 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Edition</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kentaro</au><au>Bezerra, Hiram G.</au><au>Gaur, Sara</au><au>Attizzani, Guilherme F.</au><au>Bøtker, Hans Erik</au><au>Costa, Marco A.</au><au>Rogers, Campbell</au><au>Nørgaard, Bjarne L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>44</volume><issue>2</issue><spage>580</spage><epage>589</epage><pages>580-589</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>Fractional flow reserve (FFR) has been established as gold standard to detect hemodynamically significant coronary artery disease. Non-invasive FFR derived from coronary computed tomography angiography (CTA; FFR
CT
) has demonstrated higher diagnostic performance compared with FFR. However, the accuracy and potential advantages of FFR
CT
compared with invasive FFR in coronary arteries with serial lesions have not been examined. The aim of this study was to compare trans-lesional gradient in FFR
CT
to that in invasive FFR in coronary arteries with serial stenoses. Eighteen vessels with serial coronary lesions from 18 stable angina patients were evaluated with angiography, FFR, and coronary CTA. FFR
CT
was computed from 3-dimensional CT model and coronary flow dynamics data. Multiple FFR
CT
values were co-registered with measured FFR across the lesions, and trans-lesional delta were compared between FFR
CT
and FFR. The mean values of the most distal FFR and FFR
CT
in the same co-registered regions were 0.72 ± 0.10 and 0.69 ± 0.11, respectively. In 13 vessels (72.2%), FFR was ≤0.80, while in 14 vessels (77.8%), FFR
CT
was ≤0.80. Trans-lesional delta FFR and FFR
CT
were 0.10 ± 0.09 and 0.09 ± 0.10 in distal segments, while 0.17 ± 0.10 and 0.22 ± 0.13 in proximal segments, respectively. The coefficient of correlation between trans-lesional delta FFR and FFR
CT
in each segment was 0.92 (
p
< 0.001). Trans-lesional delta FFR and FFR
CT
show an excellent correlation. Further studies are required to determine the diagnostic accuracy and clinical impact of our findings.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26329923</pmid><doi>10.1007/s10439-015-1436-y</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Angiography Arteries Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood vessels Classical Mechanics Computation Computed tomography Coronary Angiography Coronary Stenosis - diagnostic imaging Coronary Stenosis - physiopathology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Deltas Female Fractional Flow Reserve, Myocardial Humans Lesions Male Medical Stents: State of the Art and Future Directions Middle Aged Prospective Studies Segments Serials Tomography, X-Ray Computed |
| title | Comparison Between Non-invasive (Coronary Computed Tomography Angiography Derived) and Invasive-Fractional Flow Reserve in Patients with Serial Stenoses Within One Coronary Artery: A NXT Trial substudy |
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