Palladium-Catalyzed Cross-Coupling Reactions of Electron-Deficient Alkenes with N-Tosylhydrazones: Functional-Group-Controlled C--CBond Construction

In the zone: A palladium-catalyzed cross-coupling reaction of electron-deficient alkenes with N-tosylhydrazones, which affords diverse C--C bonds resulting from the functional-group-controlled effect, is reported (see scheme). These cascade transformations present remarkable stereoselectivity and a high synthetic potential. The presence of water substantially promotes both reaction routes.