Highly Efficient Rh super(I)-Catalyzed Asymmetric Hydrogenation of beta -Amino Acrylonitriles

Highly Efficient Rh super(I)-Catalyzed Asymmetric Hydrogenation of beta -Amino Acrylonitriles

It takes two to TangPhos: beta -Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos=1,1'-di-tert-butyl-(2,2')- diphospholane) catalyst system. The products, chira...

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Veröffentlicht in:Chemistry : a European journal 2010-05, Vol.16 (18), p.5301-5304
Hauptverfasser: Ma, Miaofeng, Hou, Guohua, Sun, Tian, Zhang, Xiaowei, Li, Wei, Wang, Junru, Zhang, Xumu
Format: Artikel
Sprache:eng
Schlagworte:
Acetonitrile
Acrylonitriles
Asymmetry
Catalysts
Drugs
Hydrogenation
Isomers
Nitriles
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Zusammenfassung:It takes two to TangPhos: beta -Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos=1,1'-di-tert-butyl-(2,2')- diphospholane) catalyst system. The products, chiral beta -amino nitriles, are valuable chiral building blocks for many drugs.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201000325