Allylamine and Allyl Alcohol Plasma Copolymerization: Synthesis of Customizable Biologically-Reactive Three-Dimensional Scaffolds

Plasma copolymerization is a powerful plasma‐enhanced chemical vapor deposition (PECVD)‐based technique, and offers a distinct advantage over single‐precursor PECVD of being able to deposit films with tunable functionality by adjusting the plasma precursor ratio. Here, an allylamine/allyl alcohol plasma copolymerization system was used to modify two‐dimensional (2D) and three‐dimensional (3D) substrates for biomedical applications. Films with customizable and predictable nitrogen and oxygen content, as well as surface wettability, were deposited on both Si wafers and 3D polymer scaffolds across a range of copolymerization conditions. Additionally, the bioreactivity of plasma‐modified materials was evaluated using both human dermal fibroblast and E coli attachment studies. A novel allylamine/allyl alcohol plasma copolymerization system is employed to predictably tune the surface chemistry (N/C and O/C ratios) and wettability of 2D and 3D materials for biomedical applications. Plasma‐modified 3D polymer scaffolds show enhanced bioreactivity toward human dermal fibroblasts.