Efficient Total Synthesis of Marine Alkaloid (-)-NakadomarinA

Efficient Total Synthesis of Marine Alkaloid (-)-NakadomarinA

Z's top: For the total synthesis of the marine alkaloid (-)-nakadomarinA, (-)-camphorsulfonic acid assisted, Z-selective, olefin RCM of a monoamine (less polar) rather than a diamine (more polar) was found to be highly practical for constructing the Fring. The ABCD-tetracyclic core was assemble...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry : a European journal 2011-11, Vol.17 (45), p.12569-12572
Hauptverfasser: Cheng, Bin, Wu, Fufang, Yang, Xiaobao, Zhou, Yuedong, Wan, Xiaolong, Zhai, Hongbin
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Chemistry
Construction
Diamines
Effectiveness
Marine
Olefins
RCM
Synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Z's top: For the total synthesis of the marine alkaloid (-)-nakadomarinA, (-)-camphorsulfonic acid assisted, Z-selective, olefin RCM of a monoamine (less polar) rather than a diamine (more polar) was found to be highly practical for constructing the Fring. The ABCD-tetracyclic core was assembled through a novel efficacious PtCl sub(2)-promoted cascade reaction sequence (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201102101