Design and Synthesis of 2-Methyl-7-aminobenzoxazole as Auxiliary in the Palladium(II)-Catalyzed Arylation of a beta-Positioned C(sp3)H Bond
A palladium(II)‐catalyzed direct arylation of methylene C(sp3)H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2016-03, Vol.358 (6), p.887-893 |
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| container_end_page | 893 |
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| container_issue | 6 |
| container_start_page | 887 |
| container_title | Advanced synthesis & catalysis |
| container_volume | 358 |
| creator | Luo, Feihua Yang, Jun Li, Zhengkai Xiang, Haifeng Zhou, Xiangge |
| description | A palladium(II)‐catalyzed direct arylation of methylene C(sp3)H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%. |
| doi_str_mv | 10.1002/adsc.201500834 |
| format | Article |
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| ispartof | Advanced synthesis & catalysis, 2016-03, Vol.358 (6), p.887-893 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | arylation benzoxazoles Bonding Catalysis Compatibility CH activation directing group Functional groups Methylene Selectivity Substrates Synthesis |
| title | Design and Synthesis of 2-Methyl-7-aminobenzoxazole as Auxiliary in the Palladium(II)-Catalyzed Arylation of a beta-Positioned C(sp3)H Bond |
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