Design and Synthesis of 2-Methyl-7-aminobenzoxazole as Auxiliary in the Palladium(II)-Catalyzed Arylation of a beta-Positioned C(sp3)H Bond

Design and Synthesis of 2-Methyl-7-aminobenzoxazole as Auxiliary in the Palladium(II)-Catalyzed Arylation of a beta-Positioned C(sp3)H Bond

A palladium(II)‐catalyzed direct arylation of methylene C(sp3)H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to...

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Veröffentlicht in:Advanced synthesis & catalysis 2016-03, Vol.358 (6), p.887-893
Hauptverfasser: Luo, Feihua, Yang, Jun, Li, Zhengkai, Xiang, Haifeng, Zhou, Xiangge
Format: Artikel
Sprache:eng
Schlagworte:
arylation
benzoxazoles
Bonding
Catalysis
Compatibility
CH activation
directing group
Functional groups
Methylene
Selectivity
Substrates
Synthesis
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Zusammenfassung:A palladium(II)‐catalyzed direct arylation of methylene C(sp3)H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500834