Identification of metabolites of the novel anti-tumor drug candidate MDH-7 in rat urine by liquid chromatography coupled with triple quadrupole linear ion trap mass spectrometry

Rationale Our previous preliminary pharmacokinetic study demonstrated that the novel double pyrimidine tricyclic nucleoside MDH‐7 in rats had a very short half‐life (

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Veröffentlicht in:	Rapid communications in mass spectrometry 2016-04, Vol.30 (7), p.1001-1010
Hauptverfasser:	Li, Juan, Chen, Yu, Diao, Yanyan, Su, Yingqian, Wang, Qingli, Yao, Zhicun, Yi, Tianxiang, Jin, Wenting, Zhao, Dan, Wang, Caihong, Liu, Mengru, Liu, Hongmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - urine Chromatography, Liquid - methods Drugs Hydroxylation In vivo methods and tests Liquid chromatography Male Mass spectrometry Metabolites Quadrupoles Rats Rats, Sprague-Dawley Tandem Mass Spectrometry - methods Urine
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Beschreibung
Zusammenfassung:	Rationale Our previous preliminary pharmacokinetic study demonstrated that the novel double pyrimidine tricyclic nucleoside MDH‐7 in rats had a very short half‐life (
ISSN:	0951-4198 1097-0231
DOI:	10.1002/rcm.7506