Trichloromethylthiolation of N-Heterocycles: Practical and Completely Regioselective

The first trichloromethylthiolation of a broad range of indoles and pyrroles is reported employing bench‐stable N‐trichloromethylthiosaccharin as reagent. This methodology is highly regioselective, exhibits high functional group tolerance, and provides access to two previously unknown classes of potentially bioactive compounds. No such thing! The first trichloromethylthiolation of a broad range of indoles and pyrroles using bench‐stable N‐trichloromethylthiosaccharin has been reported (see scheme). This method is highly regioselective and provides access to two previously unknown classes of potentially bioactive compounds.