Catalytic Enantioselective tert-Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5-Hydrogen Transfer

Catalytic Enantioselective tert-Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5-Hydrogen Transfer

Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5‐H transfer specifically and stereoselectively in tert‐aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer thr...

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Veröffentlicht in:Chemistry : a European journal 2012-07, Vol.18 (29), p.8891-8895
Hauptverfasser: Chen, Liujuan, Zhang, Long, Lv, Jian, Cheng, Jin-Pei, Luo, Sanzhong
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
Asymmetry
Catalysis
Catalysts
Chemistry
CH activation
hydrogen transfer
Lewis acid
Pathways
phosphoric acid
Substrates
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Zusammenfassung:Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5‐H transfer specifically and stereoselectively in tert‐aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201201532