Zinc-Catalyzed Dehydrogenative N-Silylation of Indoles with Hydrosilanes

Zinc-Catalyzed Dehydrogenative N-Silylation of Indoles with Hydrosilanes

Zinc catalysis: Zinc triflate in a nitrile solvent behaved as an effective catalyst for dehydrogenative N‐silylation with a variety of indoles and hydrosilanes (see scheme). The addition of pyridine greatly accelerated the N‐silylation reaction to produce N‐silylindoles exclusively in high to excell...

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Veröffentlicht in:Chemistry : a European journal 2012-07, Vol.18 (31), p.9500-9504
Hauptverfasser: Tsuchimoto, Teruhisa, Iketani, Yoshihiko, Sekine, Masaru
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Catalysts
Chemistry
Dehydrogenation
heterocycles
Indoles
Lewis acids
Nitriles
Pyridines
silicon
Solvents
Zinc
zinc catalysis
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Zusammenfassung:Zinc catalysis: Zinc triflate in a nitrile solvent behaved as an effective catalyst for dehydrogenative N‐silylation with a variety of indoles and hydrosilanes (see scheme). The addition of pyridine greatly accelerated the N‐silylation reaction to produce N‐silylindoles exclusively in high to excellent yields.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201200651