Catalytic and Enantioselective α-Functionalization of Oxindoles Through Oxidative Reactions with Naphthoquinones

Catalytic and Enantioselective α-Functionalization of Oxindoles Through Oxidative Reactions with Naphthoquinones

Strong as an oxindole: The enantioselective assembly of 3,3‐disubstituted oxindoles is an attractive and valuable target because of the unique properties of the oxindole core. A new organocatalyzed and enantioselective aerobic oxidative strategy for the assembly of this core structure from oxindoles...

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Veröffentlicht in:Chemistry : a European journal 2012-07, Vol.18 (31), p.9491-9495
Hauptverfasser: Siau, Woon-Yew, Li, Wenjun, Xue, Fei, Ren, Qiao, Wu, Minghu, Sun, Shaofa, Guo, Haibing, Jiang, Xuefeng, Wang, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Assembly
asymmetric catalysis
Catalysis
Catalysts
indane
organocatalysis
oxindole
Strategy
thiourea
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Beschreibung
Zusammenfassung:Strong as an oxindole: The enantioselective assembly of 3,3‐disubstituted oxindoles is an attractive and valuable target because of the unique properties of the oxindole core. A new organocatalyzed and enantioselective aerobic oxidative strategy for the assembly of this core structure from oxindoles and simple naphthoquinones is reported (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201200206