Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering
Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conj...
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| Veröffentlicht in: | Advanced healthcare materials 2012-03, Vol.1 (2), p.168-171 |
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| creator | Skaat, Hadas Ziv-Polat, Ofra Shahar, Abraham Last, David Mardor, Yael Margel, Shlomo |
| description | Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI. |
| doi_str_mv | 10.1002/adhm.201100056 |
| format | Article |
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The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201100056</identifier><identifier>PMID: 23184719</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Cell Aggregation - physiology ; Enrichment ; Ferric Compounds - chemistry ; Fibrin ; Fibrin - chemistry ; Fibrin - metabolism ; Fibrin - ultrastructure ; Health care ; Implantation ; Magnetics ; Materials Testing ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Rats ; Rats, Inbred Lew ; Scaffolds ; Three dimensional ; Tissue engineering ; Tissue Engineering - instrumentation</subject><ispartof>Advanced healthcare materials, 2012-03, Vol.1 (2), p.168-171</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4776-a210d87b4aafc943777211fd55214cbc3a85056d8fce72fc2077a5e65507c8af3</citedby><cites>FETCH-LOGICAL-c4776-a210d87b4aafc943777211fd55214cbc3a85056d8fce72fc2077a5e65507c8af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201100056$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201100056$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23184719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skaat, Hadas</creatorcontrib><creatorcontrib>Ziv-Polat, Ofra</creatorcontrib><creatorcontrib>Shahar, Abraham</creatorcontrib><creatorcontrib>Last, David</creatorcontrib><creatorcontrib>Mardor, Yael</creatorcontrib><creatorcontrib>Margel, Shlomo</creatorcontrib><title>Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering</title><title>Advanced healthcare materials</title><addtitle>Advanced Healthcare Materials</addtitle><description>Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. 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The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23184719</pmid><doi>10.1002/adhm.201100056</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cell Aggregation - physiology Enrichment Ferric Compounds - chemistry Fibrin Fibrin - chemistry Fibrin - metabolism Fibrin - ultrastructure Health care Implantation Magnetics Materials Testing Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Rats Rats, Inbred Lew Scaffolds Three dimensional Tissue engineering Tissue Engineering - instrumentation |
| title | Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering |
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