Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering

Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering

Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conj...

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Veröffentlicht in:Advanced healthcare materials 2012-03, Vol.1 (2), p.168-171
Hauptverfasser: Skaat, Hadas, Ziv-Polat, Ofra, Shahar, Abraham, Last, David, Mardor, Yael, Margel, Shlomo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Aggregation - physiology
Enrichment
Ferric Compounds - chemistry
Fibrin
Fibrin - chemistry
Fibrin - metabolism
Fibrin - ultrastructure
Health care
Implantation
Magnetics
Materials Testing
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Rats
Rats, Inbred Lew
Scaffolds
Three dimensional
Tissue engineering
Tissue Engineering - instrumentation
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Beschreibung
Zusammenfassung:Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201100056