Surface-Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome-Aided Delivery of Therapeutic Small Molecules

Surface-Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome-Aided Delivery of Therapeutic Small Molecules

The polymersome‐aided trapping of a small antitumor compound in a poly(vinyl alcohol) hydrogel matrix and the subsequent viability of myoblasts adhering to this coating is reported. The results reveal an enhanced reduction of the cell viability when the therapeutic compound is delivered from the sur...

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Veröffentlicht in:Advanced healthcare materials 2012-11, Vol.1 (6), p.791-795
Hauptverfasser: Hosta-Rigau, Leticia, Jensen, Bettina E. B., Fjeldsø, Kit S., Postma, Almar, Li, Guoxin, Goldie, Kenneth N., Albericio, Fernando, Zelikin, Alexander N., Städler, Brigitte
Format: Artikel
Sprache:eng
Schlagworte:
Adhesiveness
Alcohols
Animals
Cell Line
Chemical compounds
Coating
gold nanoparticles
Health care
Hydrogels
Hydrogels - chemistry
Mice
Molecular Weight
myoblast cell viability
Myoblasts - cytology
Myoblasts - physiology
Nanocapsules - chemistry
Nanocapsules - therapeutic use
Nanocapsules - ultrastructure
Pharmacology
Polymers - chemistry
polymersomes
Polyvinyl Alcohol - chemistry
PVA hydrogels
Surface Properties
surface-mediated drug delivery
Trapping
Viability
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Zusammenfassung:The polymersome‐aided trapping of a small antitumor compound in a poly(vinyl alcohol) hydrogel matrix and the subsequent viability of myoblasts adhering to this coating is reported. The results reveal an enhanced reduction of the cell viability when the therapeutic compound is delivered from the surface in comparison to solution‐based delivery.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200092