Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (98), p.17428-17430
Hauptverfasser:	Sugimoto, Shunsuke, Moriyama, Rui, Mori, Takeshi, Iwasaki, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Amino Sugars - chemistry Amino Sugars - metabolism Animals Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - radiation effects Cancer Carbohydrates Cell Adhesion Cell Engineering Cell Line, Tumor Circulating Cytological Techniques Fluorescent Dyes - chemistry Humans Immobilized Nucleic Acids - chemistry Immobilized Nucleic Acids - radiation effects Light Lymphocytes - pathology Macrophages Macrophages - chemistry Macrophages - physiology Mice N-Acetylneuraminic Acid - chemistry Neoplastic Cells, Circulating - pathology Nucleic acids Receptor Protein-Tyrosine Kinases - metabolism Surface Properties Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc06211j