Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells

A microfabricated device that enables morphological control and assembly of cultured single neural cells is described. Assembly of morphologically controlled single neural cells allows neuroengineers to design in vitro neural circuits with a single‐cell resolution. Compared to conventional cell‐patt...

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Veröffentlicht in:	Advanced healthcare materials 2016-02, Vol.5 (4), p.415-420
Hauptverfasser:	Yoshida, Shotaro, Teshima, Tetsuhiko, Kuribayashi-Shigetomi, Kaori, Takeuchi, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Assembly Cell Culture Techniques - methods cell handling cell patterning Cells, Cultured Circuits Devices Health care In vitro testing Laboratory apparatus Microtechnology - instrumentation neural cells neural circuits Neurites - physiology Neurons - cytology PC12 Cells Rats Single-Cell Analysis - instrumentation
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Beschreibung
Zusammenfassung:	A microfabricated device that enables morphological control and assembly of cultured single neural cells is described. Assembly of morphologically controlled single neural cells allows neuroengineers to design in vitro neural circuits with a single‐cell resolution. Compared to conventional cell‐patterning techniques, the device allows for the highly precise positioning of neural somas and neurites in a reproducible fashion.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201500782