Metal-free oxidative carbonylation on enaminone C&z.dbd;C bond for the cascade synthesis of benzothiazole-containing vicinal diketones

The cascade reactions between enaminones and o -aminothiophenols have been implemented to provide unprecedented vicinal diketones containing benzothiazole structures. The construction of the products has been realized under metal-free conditions via carbonylation on the C&z.dbd;C double bond of the enaminone. The tunable synthesis of 2-aroylbenzothiazoles has been achieved by using identical starting materials under modified reaction conditions. The tunable synthesis of benzothiazole functionalized vicinal diketones and 2-aroylbenzothiazoles has been realized by tailoring the enaminone C&z.dbd;C double bond.