Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated phospholipid vesicles

Simultaneous tracking of nanoparticles and encapsulated payload is of great importance and visualizing their activity is arduous. Here we use vibrational spectroscopy to study the in vitro tracking of co-localized lipid nanoparticles and encapsulated drug employing a model system derived from doxoru...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nanoscale 2016-02, Vol.8 (5), p.2826-2831
Hauptverfasser:	Misra, S. K, Mukherjee, P, Ohoka, A, Schwartz-Duval, A. S, Tiwari, S, Bhargava, R, Pan, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Cell Line, Tumor Cell Survival - drug effects Deuteration Deuterium - chemistry Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacology Encapsulation Humans Lipids MCF-7 Cells Microscopy, Atomic Force Microscopy, Electron, Transmission Nanoparticles Nanoparticles - chemistry Phospholipids Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemistry Spectroscopy Spectrum Analysis, Raman Tracking Vesicles X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Simultaneous tracking of nanoparticles and encapsulated payload is of great importance and visualizing their activity is arduous. Here we use vibrational spectroscopy to study the in vitro tracking of co-localized lipid nanoparticles and encapsulated drug employing a model system derived from doxorubicin-encapsulated deuterated phospholipid (dodecyl phosphocholine-d 38 ) single tailed phospholipid vesicles. Simultaneous tracking of nanoparticles and encapsulated payload is of great importance and visualizing their activity is arduous.
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c5nr07975f