A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging

A photoacoustic nanoprobe is self‐assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy‐to‐operate, and have depth‐indepen...

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Veröffentlicht in:	Advanced materials (Weinheim) 2015-11, Vol.27 (43), p.6820-6827
Hauptverfasser:	Chen, Qian, Liu, Xiaodong, Chen, Jiawen, Zeng, Jianfeng, Cheng, Zhenping, Liu, Zhuang
Format:	Artikel
Sprache:	eng
Schlagworte:	albumin Benzoates - chemistry Cell Line, Tumor Dyes Fluorescent Dyes - chemistry Human Humans Hydrogen-Ion Concentration Imaging In vivo methods and tests in vivo pH detection Indoles - chemistry Inert Models, Molecular nanoprobes Nanostructure Nanostructures - chemistry Optical Imaging - methods Oxazines - chemistry photoacoustic imaging Photoacoustic Techniques - methods Protein Conformation Real time self-assembly Serum Albumin - chemistry
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Beschreibung
Zusammenfassung:	A photoacoustic nanoprobe is self‐assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy‐to‐operate, and have depth‐independent accuracy for real‐time in vivo pH imaging of entire tumors. These features make them promising for future cancer prognosis and therapeutic planning.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201503194