Synthesis of quaternary alpha -perfluoroalkyl lactams viaelectrophilic perfluoroalkylation

Synthesis of quaternary alpha -perfluoroalkyl lactams viaelectrophilic perfluoroalkylation

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-03, Vol.52 (21), p.4049-4052
Hauptverfasser: Katayev, D, Vaclavik, J, Bruening, F, Commare, B, Togni, A
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Iodine
Ketenes
Reagents
Synthesis
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Beschreibung
Zusammenfassung:Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc00700g