Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters

Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters

Mixtures of highly curved pyridinium-decorated Au nanoparticles and standard pyridinium cationic lipids efficiently and synergetically transfected DNA in vitro, while displaying an excellent cytotoxic profile.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (1), p.60-63
Hauptverfasser: Kizewski, Adrian, Ilies, Marc A
Format: Artikel
Sprache:eng
Schlagworte:
Cationic
Cell Line, Tumor
Curved
Deoxyribonucleic acid
DNA - administration & dosage
DNA - genetics
Gold
Gold - chemistry
Humans
Lipids
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Pyridinium Compounds - chemistry
Surface-Active Agents - chemistry
Transfection
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Beschreibung
Zusammenfassung:Mixtures of highly curved pyridinium-decorated Au nanoparticles and standard pyridinium cationic lipids efficiently and synergetically transfected DNA in vitro, while displaying an excellent cytotoxic profile.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05760d