Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine

Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine

The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T-G pair over normal T-A and other mismatched pairs in the duplex context. This study pr...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-11, Vol.51 (91), p.16369-16372
Hauptverfasser: Wang, Rui, Ranganathan, Srivathsan V, Basanta-Sanchez, Maria, Shen, Fusheng, Chen, Alan, Sheng, Jia
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Base Sequence
Deoxyribonucleic acid
Grants
Molecular Dynamics Simulation
Nucleic Acid Denaturation
Oligodeoxyribonucleotides - chemical synthesis
Oligodeoxyribonucleotides - chemistry
Recognition
Stability
Synthesis
Terpenes - chemical synthesis
Thymidine
Thymidine - analogs & derivatives
Thymidine - chemical synthesis
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Zusammenfassung:The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T-G pair over normal T-A and other mismatched pairs in the duplex context. This study provides a potential explanation for the different codon recognition preferences of the geranylated tRNAs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc07479g