Direct C-H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

Direct C-H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

The rhodium(III)-catalyzed direct functionalization of aniline C-H bonds with α-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-12, Vol.51 (97), p.17229-17232
Hauptverfasser: Mishra, Neeraj Kumar, Choi, Miji, Jo, Hyeim, Oh, Yongguk, Sharma, Satyasheel, Han, Sang Hoon, Jeong, Taejoo, Han, Sangil, Lee, Seok-Yong, Kim, In Su
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Aniline
Catalysis
Chemical bonds
Formations
Indoles
Rhodium
Transformations
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Zusammenfassung:The rhodium(III)-catalyzed direct functionalization of aniline C-H bonds with α-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc07767b