A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria

A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria

We have developed a new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism. The probe showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation. The pr...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (15), p.3131-3134
Hauptverfasser: Feng, Xiao, Zhang, Tao, Liu, Jin-Ting, Miao, Jun-Ying, Zhao, Bao-Xiang
Format: Artikel
Sprache:eng
Schlagworte:
Excitation
Fluorescence
Fluorescent Dyes - chemistry
Fretting
Hydrogen sulfide
Hydrogen Sulfide - analysis
Limit of Detection
Mitochondria
Mitochondria - chemistry
Selectivity
Spectra
Wavelengths
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Beschreibung
Zusammenfassung:We have developed a new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism. The probe showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation. The probe targeted mitochondria with high selectivity and sensitivity toward H2S.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09267a