Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

An environmentally benign protocol for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines has been developed under mild reaction conditions. This approach requires Cu(OTf) sub(2) as a catalyst, and inexpensive molecular iodine as an oxidant under anionic micellar catalysis...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2015-07, Vol.17 (7), p.3728-3732
Hauptverfasser: Patel, Om PS, Anand, Devireddy, Maurya, Rahul K, Yadav, Prem P
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Catalysis
Catalysts
Iodine
Oxidants
Oxidizing agents
Synthesis (chemistry)
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Zusammenfassung:An environmentally benign protocol for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines has been developed under mild reaction conditions. This approach requires Cu(OTf) sub(2) as a catalyst, and inexpensive molecular iodine as an oxidant under anionic micellar catalysis in aqueous medium at room temperature.
ISSN:1463-9262
1463-9270
DOI:10.1039/c5gc00628g