Etude in silico des effets inhibitrices des Oleuropein, Kaempferol, et Quercetin sur le Proteine VP30 de Ebola Virus [ In silico study of the inhibitory effects of Oleuropein, Kaempferol, and Quercetin on the VP30 protein from Ebola Virus ]

Ebola is a severe viral disease that spreads in West Africa countries, whose a research on an effective Drug is a necessity. The VP30 protein is known as an essential activator transcription for Ebola virus. In another Oleuropein, Kaempferol, and Quercetin's bioactive components are several plants, and which are known by their ability of inhibiting viral transcription activators such HIV. In this context, thea uthors tested in silico by molecular modeling the ability of these substrates to inhibit VP30 by Building in the active sites, and the application of new pharmaceutical compounds although direct manipulation in vitro or in vivo is limited by the terms of Biosafety -- it is reserved for laboratory level BSL-4 -- which slow the search process. The Oleuropein components, Kaempferol, and Quercetin are linked with the active sites of VP30 with an estimated nearly -8 Kacl/mol free energy score, and an average distance of 1.8 angstrom.