Directly Observed Therapy for the Management of HIV-Infected Patients in a Methadone Program
The objective of this prospective, observational clinical study was to evaluate the safety and efficacy of once-daily and twice-daily directly observed therapy (DOT) in human immunodeficiency virus (HIV)—infected patients undergoing methadone treatment. Methadone and highly active antiretroviral the...
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Veröffentlicht in: | Clinical infectious diseases 2004-06, Vol.38 (Supplement-5), p.S402-S408 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The objective of this prospective, observational clinical study was to evaluate the safety and efficacy of once-daily and twice-daily directly observed therapy (DOT) in human immunodeficiency virus (HIV)—infected patients undergoing methadone treatment. Methadone and highly active antiretroviral therapy (HAART) were dispensed daily as DOT, with patients in the twice-daily HAART group self-administering the second dose. Clinical and laboratory end points were monitored, along with the impact of ongoing cocaine use. We studied 54 patients coinfected with HIV and hepatitis C virus. At baseline, the median virus load was 111,000 copies/mL, and the median CD4+ cell count was 165 cells/mm3. After a median of 24 months, 17 of 29 patients in the once-daily HAART group and 18 of 25 in the twice-daily HAART group had virus loads of |
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ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/421404 |