Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
Highlights • Peripheral inflammation results in affective disturbances in neuropathic pain. • Nerve injury induces increases in brain cytokine expression and glial cell activity. • Inflammation in hippocampal-prefrontal circuits causes affective disturbances. • Anti-inflammatories may prevent affect...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.397-411 |
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| container_title | Brain, behavior, and immunity |
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| creator | Fiore, Nathan T Austin, Paul J |
| description | Highlights • Peripheral inflammation results in affective disturbances in neuropathic pain. • Nerve injury induces increases in brain cytokine expression and glial cell activity. • Inflammation in hippocampal-prefrontal circuits causes affective disturbances. • Anti-inflammatories may prevent affective disturbances in neuropathic pain. |
| doi_str_mv | 10.1016/j.bbi.2016.04.012 |
| format | Article |
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| ispartof | Brain, behavior, and immunity, 2016-08, Vol.56, p.397-411 |
| issn | 0889-1591 1090-2139 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Affective behaviour Affective Symptoms - immunology Allergy and Immunology Animals Astrocytes Cytokines Hippocampus Hippocampus - immunology Hippocampus - physiopathology Humans Inflammation - immunology Inflammation - physiopathology Medial prefrontal cortex Microglia Neuralgia - immunology Neuroinflammation Neuropathic pain Prefrontal Cortex - immunology Prefrontal Cortex - physiopathology Psychiatry |
| title | Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation? |
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