Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?

Highlights • Peripheral inflammation results in affective disturbances in neuropathic pain. • Nerve injury induces increases in brain cytokine expression and glial cell activity. • Inflammation in hippocampal-prefrontal circuits causes affective disturbances. • Anti-inflammatories may prevent affect...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.397-411
Hauptverfasser:	Fiore, Nathan T, Austin, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective behaviour Affective Symptoms - immunology Allergy and Immunology Animals Astrocytes Cytokines Hippocampus Hippocampus - immunology Hippocampus - physiopathology Humans Inflammation - immunology Inflammation - physiopathology Medial prefrontal cortex Microglia Neuralgia - immunology Neuroinflammation Neuropathic pain Prefrontal Cortex - immunology Prefrontal Cortex - physiopathology Psychiatry
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Beschreibung
Zusammenfassung:	Highlights • Peripheral inflammation results in affective disturbances in neuropathic pain. • Nerve injury induces increases in brain cytokine expression and glial cell activity. • Inflammation in hippocampal-prefrontal circuits causes affective disturbances. • Anti-inflammatories may prevent affective disturbances in neuropathic pain.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.04.012