Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats

The influence of black currant juice, Bowman-Birk protease inhibitor (BBI), kolaviron (a biflavonoid fraction of Garcinia kola seed), sugars, vitamin C and tert-butyl hydroperoxide on a wide range of biomarkers for oxidative stress, DNA damage and sugar or lipid metabolism has been investigated in m...

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Veröffentlicht in:	Food and chemical toxicology 2004-08, Vol.42 (8), p.1315-1322
Hauptverfasser:	Farombi, E.O, Hansen, M, Ravn-Haren, G, Møller, P, Dragsted, L.O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants - analysis Antioxidants - pharmacology Ascorbic Acid - analysis Ascorbic Acid - pharmacology Beverages - analysis Biological and medical sciences Biomarkers Black currant black currants Bowman-Birk inhibitor Bowman-Birk protease inhibitor Carbohydrates - analysis Carbohydrates - pharmacology Comet Assay Diet DNA damage DNA Damage - physiology Enzymes - metabolism Flavonoids - pharmacology Food toxicology Fruit - chemistry fruit juices Garcinia - chemistry Garcinia kola health foods kola nuts Kolaviron Lipid Peroxidation - drug effects Lipids - blood Male Medical sciences Oxidation-Reduction Oxidative Stress - physiology Pro-oxidant Protease Inhibitors - pharmacology Protein oxidation Rats Seeds - chemistry tert-Butylhydroperoxide - pharmacology Toxicology
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Zusammenfassung:	The influence of black currant juice, Bowman-Birk protease inhibitor (BBI), kolaviron (a biflavonoid fraction of Garcinia kola seed), sugars, vitamin C and tert-butyl hydroperoxide on a wide range of biomarkers for oxidative stress, DNA damage and sugar or lipid metabolism has been investigated in male F 344 rats. The selected pro-oxidant control, tert-butyl hydroperoxide, significantly increased plasma and liver 2-amino-adipic semialdehyde (AAS), a marker of protein oxidation ( p
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2004.03.009