Benzo(a)pyrene induces interleukin (IL)-6 production and reduces lipid synthesis in human SZ95 sebocytes via the aryl hydrocarbon receptor signaling pathway

Highlights • Benzo(a)pyrene (BaP) could activate AhR signaling pathway in SZ95 sebocytes. • BaP induced interleukin-6 secretion in SZ95 sebocytes through AhR signaling pathway. • BaP inhibited lipogenesis of SZ95 sebocytes through AhR signaling pathway.

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-04, Vol.43, p.54-60
Hauptverfasser:	Hu, Tingting, Pan, Zhanyan, Yu, Qian, Mo, Xiaohui, Song, Ningjing, Yan, Min, Zouboulis, Christos C, Xia, Longqing, Ju, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acne Acne inversa AhR Benzo(a)pyrene Benzo(a)pyrene - toxicity Cell Line Cytochrome P-450 CYP1A1 - metabolism Emergency Hazardous Substances - toxicity Humans IL-6 Interleukin-6 - metabolism Lipogenesis - drug effects Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - metabolism SZ95 sebocytes
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Beschreibung
Zusammenfassung:	Highlights • Benzo(a)pyrene (BaP) could activate AhR signaling pathway in SZ95 sebocytes. • BaP induced interleukin-6 secretion in SZ95 sebocytes through AhR signaling pathway. • BaP inhibited lipogenesis of SZ95 sebocytes through AhR signaling pathway.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.02.011