Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha
Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 m...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.485-486 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Puntumchai, A Kittakoop, P Rajviroongit, S Vimuttipong, S Likhitwitayawuid, K Thebtaranonth, Y |
| description | Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively. |
| doi_str_mv | 10.1021/np030429e |
| format | Article |
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The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np030429e</identifier><identifier>PMID: 15043440</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Artocarpus - chemistry ; Artocarpus lakoocha ; Biological and medical sciences ; Drug Screening Assays, Antitumor ; Female ; General pharmacology ; Humans ; Inhibitory Concentration 50 ; KB Cells ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Nat. Prod</addtitle><description>Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Artocarpus - chemistry</subject><subject>Artocarpus lakoocha</subject><subject>Biological and medical sciences</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>KB Cells</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Roots - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Stereoisomerism</subject><subject>Stilbenes - chemistry</subject><subject>Stilbenes - isolation & purification</subject><subject>Stilbenes - pharmacology</subject><subject>Thailand</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0UtvEzEQB3ALgWhaOPAFwBc4sTB-x8dQSkGKAKmtOFoT7xhM95Ham0K_PVslIE6ex0__w5ixZwLeCJDi7bAFBVp6esAWwkhoLEjzkC1AWNWopdVH7LjWnwAz8-YxOxIGtNIaFuzbGq_HMf7IQ-UrjkPL373mA_2ayyn3d3HcYJyoZOx4nXK3oYF4O_e3OOVbqjyVseerMo0Ry3ZXebePwyfsUcKu0tPDe8KuPpxdnn5s1l_OP52u1k1S3k5NK7Ww6EBFHVtaGnRexZRI4yaCjcY7TZ4kJdXKeQzOuiQQrLKiNT6COmGv9rnbMt7sqE6hzzVS1-FA464G4fwSpHMzfH6Au01PbdiW3GO5C39PMYOXB4A1YpcKDjHX_5xVzko7u2bvcp3o9789lutgnXImXH69CO-l8Z_PQYb73Bd7n3AM-L3MmVcXEoQCcf9rxqg_No-E7g</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Puntumchai, A</creator><creator>Kittakoop, P</creator><creator>Rajviroongit, S</creator><creator>Vimuttipong, S</creator><creator>Likhitwitayawuid, K</creator><creator>Thebtaranonth, Y</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20040301</creationdate><title>Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha</title><author>Puntumchai, A ; Kittakoop, P ; Rajviroongit, S ; Vimuttipong, S ; Likhitwitayawuid, K ; Thebtaranonth, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f396t-d2416a703c4cde85a793cffe4abc06c5974e9e2ef3d2ffe0767f1a06361d59c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Artocarpus - chemistry</topic><topic>Artocarpus lakoocha</topic><topic>Biological and medical sciences</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>KB Cells</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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Nat. Prod</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>67</volume><issue>3</issue><spage>485</spage><epage>486</epage><pages>485-486</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>15043440</pmid><doi>10.1021/np030429e</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Artocarpus - chemistry Artocarpus lakoocha Biological and medical sciences Drug Screening Assays, Antitumor Female General pharmacology Humans Inhibitory Concentration 50 KB Cells Medical sciences Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Stereoisomerism Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology Thailand Tumor Cells, Cultured |
| title | Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha |
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