Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha

Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 m...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.485-486
Hauptverfasser:	Puntumchai, A, Kittakoop, P, Rajviroongit, S, Vimuttipong, S, Likhitwitayawuid, K, Thebtaranonth, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Artocarpus - chemistry Artocarpus lakoocha Biological and medical sciences Drug Screening Assays, Antitumor Female General pharmacology Humans Inhibitory Concentration 50 KB Cells Medical sciences Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Stereoisomerism Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology Thailand Tumor Cells, Cultured
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Zusammenfassung:	Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030429e