Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis

Aim We aimed to examine the relationship between the Wisteria floribunda agglutinin positive Mac‐2‐binding protein (WFA+‐M2BP) level and high‐sensitivity C‐reactive protein (hCRP) concentration and liver histological findings for patients with autoimmune hepatitis (AIH). Methods A total of 84 AIH patients (median age, 64 years) were analyzed. We examined the effect of pretreatment WFA+‐M2BP level and hCRP concentration on histological findings of liver fibrosis and liver inflammation activity comparing with other laboratory markers. Receiver–operator curve (ROC) analysis was performed for calculating the area under the ROC (AUROC). Results The median WFA+‐M2BP values in each fibrosis stage were: 1.5 cut‐off index (COI) in F1, 2.1 in F2, 3.3 in F3 and 9.8 in F4 (P